, NLR family pyrin domain containing 3 (NLRP3)) that sense pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), such as the accumulation of ROS or the efflux of potassium ions (K + )
A low total-glutathione result may have several causes, and blood glutathione does not perfectly represent glutathione concentrations in every tissue
The observation in this study in hepatocytes that protein-SSG formation by either GSSG accumulation or treatment with a direct S -glutathionylation induction agent resulted in IKK--SSG formation, leading to its suppression, was supported by a previous study reporting that S -glutathionylation was associated with suppressed IKK- activity in epithelial cells 41
While glutathione is generally recognized as safe (GRAS), there is a potential for side effects to occur
doi: 10.3390/jcm12030893 [DOI] [PMC free article] [PubMed] [Google Scholar] 46.Anggraini DR, Feriyawati L, Sitorus MS, Syarifah S, Daulay M