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Todorov on smartskincare writes this: "..excessive use can have an opposite effect by increasing the levels of free copper and/or by triggering excessive production of metalloproteinases

This has led researchers to investigate a possible association with premature graying

Future directions to overcome these challenges include biomarker-driven clinical trials that enrich enrollment with patients exhibiting high mtDAMPs or immune dysfunction, such as testing NLRP3 inhibitors in cardiac surgery patients with elevated preoperative neutrophilplatelet aggregates or high mtDNA levels after CPB, thereby increasing the power to detect benefits in those most likely to respond

BPC-157s neuroprotective properties are relevant here it may help reduce inflammation around the spinal cord and support nerve regeneration