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Activation of both GIP and GLP-1 receptors by retatrutide probably contributed to the observed changes in circulating triglycerides, as treatment with the dual GIP/GLP-1 receptor agonist tirzepatide significantly reduced triglyceride levels by up to 29% at 52 weeks in a clinical trial in people with T2D and MASLD 8

Major Findings: Developed LY3437943 (retatrutide), a novel triple agonist targeting the GLP-1, GIP, and glucagon receptors