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2,3 DUAL-I The DUAL- I study was an open-label, treat-to-target trial which recruited 1,663 adults with type II diabetes inadequately controlled with metformin with or without pioglitazone (HbA 1c 710%)

Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the Ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations recommendations and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb

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