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[1] [2] Extensive clinical trial data from the SURPASS program (for diabetes) and SURMOUNT trials (for weight management) involving thousands of participants did not identify epistaxis as a significant adverse event associated with tirzepatide use

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(16) demonstrated that the hepatitis B virus X protein (HBx) downregulates miR-145, leading to upregulation of CUL5, which promotes cell cycle progression (from G0/G1 to G2/M) and inhibits apoptosis

Continuous hyperserotonemia in Sert / mice, which was 2-fold higher than controls, produced smaller placentas, marked cell death, and necrotic lesions that were similar to placentas from HDP women (257)