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Keywords: type 2 diabetes, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide Introduction: The Incretin Effect in Health and Disease The gastrointestinal system has an intricate pathway of hormones that are released from the gut lining upon ingestion of food and regulate glucose metabolism and appetite

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Early studies discovered a reduced incretin effect in individuals with type 2 diabetes following oral glucose intake 16,17,18