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Cell 8 , 343352 (2005)
The diluent you choose, the technique you apply, and the math behind your dosing all determine whether a vial of expensive peptide yields clean, repeatable data or a contaminated, denatured mess
Kalaany and Sabatini had shown in NOD-SCID (non-obese diabetic, severe combined immunodeficient) mice that xenografted tumors with constitutive activation of AKT by either gains in PIK3CA or loss of PTEN are resistant against CR, and insensitive to insulin and IGF-1 treatment in vitro
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