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In recent years, emerging allosteric modulators have been developed that recognize allosteric sites other than orthosteric sites and modulate receptor activation by changing the conformation of the receptor 7,8 , which has the advantages of high selectivity, overcoming resistance to orthosteric modulators, and expanding the concept of target sites

The SURMOUNT-5 trial showed 20.2% vs 13.7% weight loss, and Second Natures real-world data showed 22.1% vs 17.1%

Circulation 148 , 23484 (2023)

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246-248 In women, obstructive sleep apnea is associated with poor pregnancy outcomes, including gestational diabetes, preeclampsia, and fetal growth restriction