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Research indicates that the metabolic reprogramming of tumor cells leads to the overproduction and accumulation of ammonium, which directly disrupts immune cell functions, inhibiting T cell proliferation and cytotoxicity (112)

Curr Chem Biol

Ultrasonication: Ultrasonication applies high-frequency sound waves to reduce the size of multilamellar vesicles (MLVs) into smaller unilamellar vesicles (SUVs)