Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)
10.1074/jbc.274.46.33148 345 YoshiokaK.OtaniH.ShimazuT.FujitaM.IwasakaT.ShiojimaI
In support of this notion, it has been shown that the inhibitory effect of UA on GSIS in rat pancreatic islets has a sudden occurrence at a threshold of 6.7 mg/dL (0.4 mM) [37]
You have to have faith that its working for you. Potential Side Effects and Precautions of NAD Supplements Some minor side effects that could be tied to NAD supplementation include: Headache Diarrhea Nausea Flushing Rashes Abdominal discomfort Digestive issues But again, the safety of NAD is pretty sound
No, Results take time, usually weeks to months
