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This neurotropic combination (Thiamine B1 + Pyridoxine B6 + Cyanocobalamin B12) is used for: peripheral neuropathy (diabetic/alcoholic), nerve compression syndromes, vitamin deficiency states, and chronic pain management

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Berthoux C, Hamieh AM, Rogliardo A, Doucet EL, Coudert C, Ango F, et al

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant)