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406,407 Interestingly, IDH1 mutants compete for NADPH to synthesize 2-HG with other pathways that are critical for cell viability, resulting in further disruption of cellular metabolism and redox homeostasis in tumorigenesis

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2.2 8.8%, p = 0.09, p 2 = 0.03, power = 0.38) GSH relative to the control group, but not in the frontoparietal ( p = 0.24) or frontal regions ( p = 0.47)