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Additionally, medications such as saxagliptin and metformin have demonstrated effectiveness in regulating -cell function by reducing inflammation in newly diagnosed T2DM patients with PCOS (74).These findings suggest that the crucial role of pancreatic inflammation and -cell dysfunction in PCOS-related metabolic complications and highlight the need for targeted interventions that can improve -cell function and reduce inflammation

Shimoni A, Anderlini P, Andersson B, Andreeff M , Braunschweig I, Claxton D, Cohen A, Donato M, Estey E, Gajewski J, Khouri I, Korbling M, Kornblau S, Molldrem J, Ueno N, Champlin R, Giralt S