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According to the Uniport data bank, GPX4 contains 197 residues with a molecular mass of 22 kDa

And in a system with high receptor expression the constitutive signal can dominate the ligand-dependent one, which is why an inverse agonist control is more informative here than a plain vehicle control

For example, Edy Kornelius et al

Regarding exenatide, Trevaskis et al

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