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Our findings confirm that longer diabetes duration is associated with a lower glycaemic response to GLP-1 RAs [3, 6, 16], probably due to declining beta cell function, as intact insulin secretion is necessary for a robust glycaemic response to this drug class [1, 3]

Prescription GLP-1 Medications: Mechanism, Cost, and Clinical Evidence GLP-1 receptor agonists (semaglutide, tirzepatide) work by increasing satiety signals in the brain, slowing gastric emptying, and improving insulin secretion

Engaging in regular physical activity not only aids in burning calories but also promotes healthy metabolism and boosts mood and energy levels

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We demonstrate large myocardial areas which are above the normal values for T1 relaxation times and extracellular volume fraction indicating increased presence of myocardial fibrosis in left ventricular myocardium of these individuals without overt CV disease