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In vitro protein phosphorylation mass spectrometry raw data have been deposited in the MassIVE repository ( under accession MSV000101031 ( The source data of this paper are collected in the following database record: biostudies:S-SCDT-10_1038-S44319-026-00818-0

keywords Angiogenesis breast cancer chemotherapy drug resistance vascular normalization immunologic therapy tumor microenvironment (TME) Introduction Breast cancer is currently the most prevalent type of cancer among women 1 , and its incidence is increasing every year 2

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