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Like tBHP, CHP markedly induced cell death and HMGB1 release in cardiomyocytes, which was effectively inhibited by ferroptosis inhibitors such as Fer-1, DFO, and liproxstatin-1 (Lip-1) (Fig

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Along this line, it has been hypothesized that decreased levels of GSH, which have been detected in post-mortem brains of parkinsonian patients at the cellular level, are likely to affect mitochondrial functions via loss of mitochondrial GSH