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Weight loss under the action of GLP-1RA is not only caused by acting on the hypothalamus or parasympathetic nervous system, thereby inhibiting appetite and delaying gastric emptying, but also by acting on white and brown adipocytes

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The trial compared injectable semaglutide (1mg) once weekly with a placebo as an adjunct to the standard of care for the prevention of major kidney outcomes, specifically kidney failure, substantial loss of kidney function, and death from kidney or cardiovascular causes