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Clarifying the mechanisms underlying these effects requires deeper exploration of tirzepatides distinct physiological actions beyond glucose control

GLP-1 medications, such as Ozempic, Trulicity, and Wegovy, are designed to replicate these natural actions of GLP-1

While selective activation of PPAR by fibric acid derivates (fibrates) primarily improves hepatic lipid and cholesterol metabolism 3 , the selective activation of PPAR by thiazolidinediones (TZDs) enhances insulin sensitivity in peripheral tissues such as the adipose tissue, liver and skeletal muscle 4

Thyroid Issues: The drug carries a black box warning for thyroid C-cell tumors in rodents, leading to human concerns about thyroid cancer, especially over extended use

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