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Patients with insulin resistance or elevated fasting glucose may experience more pronounced gut slowing initially, as GLP-1 therapy shifts metabolic priority toward glucose regulation

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The reduction in MACE observed in treatment with GLP-1RAs is mainly driven by a significant reduction in fatal or non-fatal stroke, but also a significant reduction in risks for CV death and fatal or non-fatal myocardial infarction (15), suggesting that GLP-1RAs may exert their cardioprotective effects through anti-atherosclerotic mechanisms