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Chen K, Song L, Jin MJ, Fan CH, Cao J, Yu WP

It signals that the approved use is chronic management rather than a defined course with an end date, which reframes the question from "how long until I finish" to "how long until the trajectory is established, and what happens after." An Intermediate Marker Around Five Months The clearest published mid-course number comes from STEP 4, which used a 20-week run-in 16 weeks of dose escalation plus four weeks at the maintenance dose before randomizing participants

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In the SURMOUNT-1 trial, patients lost up to 20% of body weight at higher doses, making it the most effective option available to date