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That said, here are some groups of people who are typically not candidates for semaglutide or advised to use it with caution: History of Pancreatitis Individuals with a history of pancreatitis, which is inflammation of the pancreas, should avoid semaglutide due to the potential risk of exacerbating the condition

J Pharm Investig 51:117135

The ruptured cells then release stored fat, which is naturally metabolized and eliminated by the body's lymphatic system over several weeks