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(136) showed that GLP-1RAa have the effect of lowering blood pressure

These improvements appear to extend beyond what would be expected from glucose lowering and modest lipid changes alone

Research shows that GLP-1 receptor-like signals are present in colon nerves and elevated in irritable bowel syndrome (IBS) patients, possibly explaining the presence of more nerve fibers in their colon [106]

You also need to have tried everything else and be unable to join a clinical trial

GIP+GLP-1 is a multi-functional treatment solution that primarily helps with weight loss by suppressing appetite and delaying gastric emptying , promoting fat burning