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At 6 years, he developed fine motor coordination delay, swallowing difficulty with frequent choking, bilateral ptosis, as well as exercise intolerance, intermittent muscle soreness, and generalized muscle weakness affecting mainly his trunk and proximal muscles

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2.10.1 Limitation of in-vitro model Despite their value in mechanistic research, in vitro models present several critical limitations that constrain their translational applicability (Blanchard et al., 2022)

Purinergic signalling underlies transforming growth factor--mediated bladder afferent nerve hyperexcitability