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Adjusting doses or timing of these medications may be necessary to optimize blood sugar control while minimizing side effects

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What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have

The GLP-1 receptor agonist dose should be lowered and patients should be encouraged to increase meal size and frequency