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Contraindications to Semaglutide include: a personal history of pancreatitis, alcohol abuse, renal impairment, uncontrolled psychiatric disorders, personal or family history of medullary thyroid carcinoma (MTC), or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), and if you are pregnant or breastfeeding

Anyone with fatigue, vegetarians/vegans, people with absorption issues, or those wanting a safe energy boost

If b12 comes back low, add supplementation

The liver stores substantial quantities of vitamin B12, and hepatocellular damagefrom conditions such as cirrhosis, hepatitis, or hepatocellular carcinomacan release these stores into the bloodstream

Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)