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Quick definition: Leaky gut refers to increased intestinal permeability a more porous gut barrier that lets bacterial fragments, undigested food particles, and toxins cross into deeper tissue more readily

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One of the reasons for the development of ADRs of toxic VPA metabolites is the induced carnitine deficiency due to the excretion of valproyl-carnitine by the urine [117] and, as a consequence, impaired mitochondrial oxidation [118]