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PMID: 58 KelleySTSkarraDVRiveraAJThackrayVG
HGF binds to c-MET via two distinct sites: A low-affinity binding site within the SPH domain, which interacts with the SEMA domain of c-MET A high-affinity binding site located at the N-terminus and K1 domain, which interacts with the IPT3IPT4 region of c-MET Schematic representation of c-MET and HGF structures and binding sites [1] The c-MET Signaling Pathway c-MET is primarily expressed on the surface of epithelial cells, where it plays a fundamental role in embryogenesis, wound healing, and organ regeneration
Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al
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