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In the previously described multicenter retrospective study of over 500 patients, pruritis (3.3%), flushing (2.0%) and urticaria (1.3%) were the most reported symptoms potentially suggestive of anaphylactoid reaction in the IV NAC cohort, with significantly lower rates in the oral cohort [83]

Most clinical studies have examined these substances independently rather than in combination, so the safety profile and potential synergistic or additive effects remain inadequately characterised

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Bull Hosp Jt Dis Orthop Inst

10.1111/bpa.12655 Brain Pathol