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However, GLP-1R is expressed in numerous neural populations distributed throughout the CNS (54), and functional mapping of the role of each of these in maintaining energy balance, in effecting GLP-1RAinduced weight loss, and in inducing GLP-1RA side effects remains the subject of intense study

Overall, weight loss depends on a sustained Calorie deficit for weeks to months, as an individuals average intake over weeks and months is more predictive of weight change than a single day

New York: Knopf

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