Before first use, the concern is the shelf life of a sealed preparation
Here are some cosmetic mechanisms that may contribute to improved appearance: 1
Effect of MELANOTAN, [Nle4, D-Phe7]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles Peptides, 2006, melaninrespons vid MC1R-varianter PMID 12591111 Ter Laak MP et al
Faster tendon healing in animal models Journal of Applied Physiology, 2011 Knee pain relief in human patients Journal of Orthopaedic Surgery and Research, 2021 Safety profile across soft tissue indications Current Pharmaceutical Design, 2019 The statements on this page have not been evaluated by the Food and Drug Administration
Tesamorelin's Phase 3 trials and Sermorelin's original approval studies were built around HIV-associated lipodystrophy and pediatric growth failure, not muscle building, so their bodybuilding use rests on extrapolation rather than direct testing