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FIGURE 1 2.1 Metformin promotes follicular development and ovulation induction 2.1.1 Promoted autophagy in follicular granulosa cells Promoting follicular development and inducing ovulation are cornerstones in the management of infertility in PCOS

Collaborative Approach We collaborate with other providers, including primary care, physical therapists, vision and vestibular specialists, and other experts to ensure comprehensive support

This regimen (shown as a 50:50 dosage ratio) is more difficult to adjust because NPH has both a 2 hour delay, limited duration of action, and a time course that gives it prandial-like properties that can result in different levels of insulin stacking when another prandial insulin is given concomitantly (see Figure 14)

Journal reference: Mazza T, Scalise M, Console L, et al