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These findings positioned DHODH as a third axis of ferroptosis defense, alongside GPX4 and FSP1, particularly in mitochondria-rich or metabolically active cell types

Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer

Proteinase 3 (ANCA) : Typically found in autoimmune diseases that cause blood vessel inflammation

A phase I safety study in healthy adults confirmed that subcutaneous MOTS-c injections at doses up to 10 mg produced no serious adverse events, with a pharmacokinetic profile supporting once-daily or every-other-day dosing [3]

Adipose-derived stem cell (ASC) and BMSC delivery has also been shown to promote disc regeneration in an experimentally induced IVD degeneration in (Beagle [24]) dogs [25]