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This was further corroborated by ultrastructural analysis of SNAP-GLP-1R subcellular distribution by electron microscopy, which revealed greater receptor localization to tubular recycling endosomes and PM following exendin-phe1 vs

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Both are once-weekly injections from Eli Lilly, but retatrutide adds a third hormone receptor (glucagon) on top of the GLP-1 and GIP receptors that tirzepatide already targets