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Unopened lyophilized powder is more forgiving and can tolerate brief room-temperature periods, but a reconstituted vial needs consistent refrigeration and should be used within 28 days, the window supported by bacteriostatic water's antimicrobial preservative

Heat shock proteins (HSPs) play a role of central importance in protecting cells from damage by inflammation, oxidative stress, and other causes (116)

Weight loss, regardless of the method achieved, fundamentally alters how the body regulates temperature

The severity of vomiting crises was subjectively evaluated by the parents

Exposure to sunlight is a known trigger for melasma, and the condition may worsen with UV exposure