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As a marker of oxidative stress, GGT expression in advanced tumor cells surpasses that in early tumor cells

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Similarly, genetic deletion or pharmacological suppression of 5-lipoxygenase (5-LO) in mice led to induction of phase II detoxification enzyme SULT2A1 and inhibition of the pro-toxic phase I enzyme CYP 3A11, which subsequently reduced NAPQI formation and finally ameliorated AILI [94]