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Annu Rev Pharmacol Toxicol 43:23360 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Voxelotor significantly improved Hb levels in patients with a variety of comorbidities, including serious renal failure, oxidative stress, and severe anemia with initial Hb values in the range of 5.2 g/dl in a case series of 7 SCD patients [85,86,87,88,89]

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