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Rosenstock J, Cefalu WT, Lapuerta P, Zambrowicz B, Ogbaa I, Banks P, Sands A

Wegovy may be prescribed for weight loss, reducing the risk of cardiovascular disease, or treating advanced liver disease

People with liver disease need caution because the liver is central to both ketone production and the metabolism of many GLP-1 medications

Results reviewed here support the idea that mesolimbic GLP-1R are sufficient to reduce hunger-driven feeding, the hedonic value of food and food-motivation

Severe renal impairment appears again in its safety section as a factor requiring careful evaluation before either drug is started, alongside pancreatitis history and retinopathy