This is the dose where "forgetting to eat" becomes common, where portion sizes shrink noticeably, and where the relationship with food begins its most visible shift
Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal W, Kumar A, Winstanley CA, Renthal NE et al (2007) IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
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Its one of the reasons it works for weight management
While counterfeiters change lot numbers regularly, checking the FDA website for currently known counterfeit lot numbers is a simple precaution