Clinical Update 10/28/2024 This May Reduce Leg Cramps A recent study found high-dose vitamin K to dramatically reduce nighttime leg cramps in older men and women
Theres likely to be some sticker shock for many, and whether theyll be able to continue to afford the therapy remains to be seen. Affordability and access remain concerns for some health care professionals
Why Weight Regain Occurs : Biological adaptations that promoted weight gain initially remain present Appetite and food preoccupation often return when medication stopped Metabolic rate may decrease during weight loss (adaptive thermogenesis) Hormonal changes that defend against weight loss persist Long-Term Management : Most individuals require ongoing medication for sustained weight loss maintenance This is similar to other chronic disease treatments (e.g., blood pressure medications) Obesity is a chronic disease requiring long-term management Strong lifestyle habits help minimize regain but may not prevent it entirely Discuss any plans to discontinue medication with healthcare provider to develop appropriate tapering plan and maintenance strategies
Its framing is that GLP-1 is a central regulator of metabolic homeostasis your body already produces, not a foreign substance introduced by medication
In the case of liraglutide, it has been observed that the lipid tail promotes the aggregation of the peptide into hexa-, hepta-, or octamers, remaining in this oligomeric form under specific pH or ionic strength conditions
