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According to the cryo-EM analysis, it engages the ECD, extracellular loop 2, and transmembrane helices 1, 2, 3, and 7 while notably not contacting helices 4, 5, and 6, which the peptide relies on

[14] [15] Heart rate changes: GLP-1 receptor agonists are associated with a modest increase in resting heart rate

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Sudden heart palpitations or dizziness: Especially during or after a heavy set

It should not be given to children or patients with a known allergy to GLP-1 receptor agonists