Its recommended that you inject yourself on a weekly basis in your upper arm, stomach, or thigh
Stomach side effects can be more common with higher doses
Gastroparesis (Stomach Paralysis): In severe cases, the stomach slows down so much that it effectively stops moving food forward
Consistent with downregulation of the CCK signaling pathway, exogenous CCK administration (2 or 4 g/kg bodyweight) effectively reduced food intake in fasted WT controls (Figure 4G), demonstrating functional CCK signaling
For this review, we evaluated recommendations from the Japanese Circulation Society / Japanese Heart Failure Society (JCS/JHFS 2025), American Heart Association (AHA 2022), and European Society of Cardiology (ESC 2021/2023), as these represent widely cited, contemporary international guidelines that incorporate the most up-to-date clinical trial evidence and offer complementary perspectives across different healthcare systems