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In addition to pancreatitis, among the moderate clinical priority signals, the most commonly reported semaglutide-related AEs were nausea (score 6), vomiting (score 6), diarrhea (score 5), constipation (score 6), and abdominal pain (score 5), and so on, which were consistent with the drug label

Proc Natl Acad Sci USA 99:30473051

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This means that they are still making glutathione, but they dont keep enough of it around to protect them from oxidative stress

Because glutathione and vitamin C combine two of the body's most important antioxidants, the benefits extend well beyond skin appearance