Cyril Bowers at Tulane synthesized it in 1980 as a derivative of met-enkephalin opioid peptides not, interestingly, because he was trying to build a GH secretagogue
Am J Hum Genet 59(2):475 Caron NS, Wright GE, Hayden MR
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The IgE binds to receptors on mast cells and basophils, and histamine released (rapidly)