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One major event that happens early after insult is the massive ionic influx referred to as traumatic depolarization

The LEADER and SUSTAIN-6 trials demonstrated that semaglutide reduces the risk of major adverse cardiac events, including heart attack and stroke, particularly in patients with existing type 2 diabetes or cardiovascular disease

Simultaneously, the weight-loss effect induced by the initial administration lasted approximately one week, whereas the weight-loss effect from the second administration lasted about 48 hours (Figure 4A)

The American Journal of Psychiatry, 153 (9), 12191221

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