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Fang Y, Elahi A, Denley RC, Rao PH, Brennan MF, Jhanwar SC

In metastatic disease, capecitabine and 5-FU in combination with either cisplatin or oxaliplatin are still first-line treatment options [151]

The sham procedure is similar and consists of laparotomy without renal pedicle clamping

Assessing changes in either large cerebral artery cross-sectional area and CBF (MRI) or cerebral hemodynamics (MCAv) in response to a vasoactive stimuli, such as carbon dioxide (CO 2 ), forms the basis of cerebrovascular reactivity (Wang et al., 2023)