In contrast, SAGE-DM is not a cluster-defined or statistically derived phenotype, but a mechanistically oriented framework emphasizing the role of aging biology rather than clinical clustering
Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, et al: Extension of life-span with superoxide dismutase = catalase mimetics
The Peter Attia Drive Total duration: 49 h #401 How curiosity transforms medicine: extraordinary discoveries that changed modern healthcare The Peter Attia Drive 64:00 #400 AMA #87: Environmental pollution and longevity: air pollution, noise, light, EMFs, and practical strategies to mitigate health risks The Peter Attia Drive 19:41 #399 The evolution of Alzheimer's disease and dementia care: how early detection, personalized treatment, new therapies, and a multimodal approach are changing the landscape | Gayatri Devi, M.D
Dose Range: 200500 g daily (adult research range
Petersburg, Russia Initial research in 1980s at Institute of Bioregulation and Gerontology Derived from studying pineal gland peptides and aging Over 40 years of Russian research (but limited Western studies) Inspired by observation that pineal gland function declines with age Why developed: Soviet/Russian focus on longevity research Searching for ways to extend healthy lifespan Understanding cellular aging mechanisms Pineal gland's role in aging and circadian rhythms Goal: Create synthetic peptide mimicking natural bioregulators Epithalon vs epithalamin: Epithalamin: Natural polypeptide complex from pineal glands (bovine) Epithalon: Synthetic tetrapeptide mimicking epithalamin's active component Epithalon more practical (synthetic production, consistent quality) Both target similar anti-aging pathways Learn peptide fundamentals and how peptides work at SeekPeptides to understand Epithalon's unique mechanisms
