glp 1 hormone production Glucagon-like peptide-1 receptor: mechanisms and advances in therapy GLP-1: Actions on Beta-cell Mass

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Vitamin D3 is better than vitamin D2 for this purpose since vitamin D2 potency is less than one third that of vitamin D30F.38 Multiple studies have demonstrated that vitamin D3 and calcium can decrease postmenopausal bone loss, help prevent osteoporosis and decrease the risk of fractures 145F39 146F40 147F41 148F42 149F43 150F44 151F45 152F46 153F.47 Other research has demonstrated that vitamin D with calcium or vitamin D alone improved bone mineral density compared with no therapy 124F48 125F.49 Likewise, a large clinical trial 138F50,51 found that supplementing with a high dose of vitamin D3 for two years helped reduce declines in in bone mineral density

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The researchers compared the one-year risk of heart failure hospitalization or death in new users of each GLP-1 drug to the risk of those outcomes in a placebo group of patients taking sitagliptin, a diabetes drug known to have no impact on HFpEF