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In preclinical studies conducted at Cornell University in laboratory cats, no adverse effects or unanticipated events were observed

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12 This imbalance in retinopathy outcomes was absent in SUSTAIN 15 trials, yet not infrequently reported following abrupt glycaemic improvement (such as in Diabetes Control and Complications Trial and in newly diagnosed patients with T2D in the UK Prospective Diabetes Study (UKPDS 33), or in introduction of insulin in everyday clinical practice)