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Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids

A February study of more than 98,000 U.S

Additionally, GLP-1 drugs slow down gastric emptying, helping to regulate appetite and promote weight loss in some individuals

Ahrn B, Hirsch IB, Pieber TR et al (2016) Efficacy and safety of liraglutide added to capped insulin treatment in subjects with type 1 diabetes: the ADJUNCT TWO randomized trial